Thrombin Plasma prep for Exosome precipitation (500 ul at 500U/mL)

Efficient exosome isolation from plasma

"We therefore pursued the ExoQuick^® method for further study, as these samples required much less sample input, a key benefit when working with clinical samples and mouse models¹."

When isolating exosomes from plasma, fibrinogen and fibrin can impede efficient recovery. By pre-treating plasma with thrombin, the fibrinogen can be converted to fibrin and easily pre-cleared by a simple centrifugation step. The resulting serum-like solution can now be treated with ExoQuick, original formulation, for quantitative exosome isolation that is compatible with high-throughput methods.

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REFERENCES

1. Chugh PE, et al. Systemically Circulating Viral and Tumor-Derived MicroRNAs in KSHV-Associated Malignancies. PLoS Pathog. 2013.9(7): e1003484. PMCID: PMC3715412.